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Synthesis of [<sup>18</sup>F]Arenes via the Copper-Mediated [<sup>18</sup>F]Fluorination of Boronic Acids
243
Zitationen
7
Autoren
2015
Jahr
Abstract
A copper-mediated radiofluorination of aryl- and vinylboronic acids with K(18)F is described. This method exhibits high functional group tolerance and is effective for the radiofluorination of a range of electron-deficient, -neutral, and -rich aryl-, heteroaryl-, and vinylboronic acids. This method has been applied to the synthesis of [(18)F]FPEB, a PET radiotracer for quantifying metabotropic glutamate 5 receptors.
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