Development of an Image Analysis-Based Prognosis Score Using Google’s Teachable Machine in Melanoma

Abstract

BACKGROUND: The increasing number of melanoma patients makes it necessary to establish new strategies for prognosis assessment to ensure follow-up care. Deep-learning-based image analysis of primary melanoma could be a future component of risk stratification. OBJECTIVES: To develop a risk score for overall survival based on image analysis through artificial intelligence (AI) and validate it in a test cohort. METHODS: Hematoxylin and eosin (H&E) stained sections of 831 melanomas, diagnosed from 2012-2015 were photographed and used to perform deep-learning-based group classification. For this purpose, the freely available software of Google's teachable machine was used. Five hundred patient sections were used as the training cohort, and 331 sections served as the test cohort. RESULTS: = 101) showed an overall survival rate of 77.2%. CONCLUSIONS: The study supports the possibility of using deep learning-based classification systems for risk stratification in melanoma. The AI assessment used in this study provides a significant risk estimate in melanoma, but it does not considerably improve the existing risk classification based on the TNM classification.

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