A longitudinal analysis of morphological shape variation of spleen in patients with Fontan surgery

Abstract

Splenic size serves as a surrogate biomarker for predicting portal vein hyper- tension and liver abnormalities in subjects with Fontan Associated Liver Disease (FALD). We analyze the long-term shape variation of the spleen in FALD subjects using morphological shape features of radiomic features. We used 154 (84 from computed tomography and 70 from magnetic resonance) image volumes obtained from 36 individuals who underwent stage 3 Fontan procedure and 145 computed tomography images from controls to assess splenomegaly. To understand the splenomegaly, thirteen shape features of the spleen over three 10-year intervals, and variations between controls and FALD subjects were analyzed. The spleen enlargement was observed in all intervals of the post-surgery period. Also, a significant difference (level of significance α = 0.05, p < α ) was observed between the morphological shape features of controls and the Fontan Associated Liver Disease subjects. Morphological shape features clearly distinguish between controls and subjects after Fontan stage 3 correction.

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